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Image of teenagers hanging out by a pool. Text on image says “Signs and Features”
What are the signs and features of PROS?

Although the conditions in the PIK3CA-Related Overgrowth Spectrum, or PROS, group are caused by the same mutation, they can look very different from each other in the following ways:

  • How they appear on the body, such as the size, shape, and type of growth or malformation

  • Where they are located on the body

  • Which features and complications they cause over time

It is important to note that, while your specific PROS condition determines the features that may appear, someone else with the same condition can experience very different features.

Examples of common PROS features

Image of person with enlarged head

Enlarged head

Head enlargement may occur when brain complications, such as hydrocephalus (fluid in the brain) or seizures, result in brain overgrowth. This may also cause neurologic problems. These are most prevalent in MCAP/M-CM and HME/DMEG/focal cortical dysplasia type II.

Image of person with enlarged digits

Enlarged digits

One or more fingers or toes is unusually large.

Image of person with lymphatic malformations

Lymphatic malformations

These occur when vessels containing a clear fluid, called lymph, grow abnormally.

Image of person with vascular malformations

Vascular malformations

These occur when vessels, such as arteries, veins, and capillaries, do not develop in the usual manner. These malformations may cause blood flow to be too fast or too slow.

Image of person with abnormal growth

Abnormal growth

When certain parts of the body grow abnormally fast or slow. Muscles, fatty tissue (such as a lipoma), organs, the spine or skeleton, and the skin’s surface may be affected.

It is also common to experience pain and fatigue from one or more of these PROS features.